4 Signs Your Depression Might Benefit from Spravato™ Treatment

Depression looks different for everyone. Some people find relief with the first medication they try. For others, symptoms linger — no matter how many prescriptions or adjustments are made. If that sounds familiar, it may be time to consider a different approach.

At Revive Holistic Psychiatry in Weymouth, Massachusetts, we help patients who feel like they’ve “tried it all” finally find a treatment that works. 

Dr. Oluranti Adepoju, our skilled and compassionate psychiatrist, offers Spravato™ (esketamine) nasal spray, an FDA-approved option for treatment-resistant depression. It works differently from standard antidepressants and can bring relief when other options fall short.

Spravato isn’t the first step in depression care, but it may be the right step if you’ve been through other treatments without success. Here are four key indicators that it might be time to consider Spravato.

1. You’ve tried multiple antidepressants without lasting relief

Most traditional antidepressants — SSRIs and SNRIs — target neurotransmitters like serotonin and norepinephrine. They can take weeks to build up in your system, and for many patients, results are disappointing or temporary.

Spravato works differently. It targets NMDA receptors in the brain, helping reset how nerve cells communicate. This means it can relieve symptoms faster — sometimes within hours to days — especially when standard medications haven’t helped.

If you’ve already cycled through two or more antidepressants with little success, Spravato could be a next step worth exploring.

2. Your depression makes daily life feel unmanageable

Depression isn’t just feeling sad. It can interfere with sleep, appetite, work, and relationships. If you find that getting through a normal day feels overwhelming, you may be a candidate for Spravato.

Unlike oral medications you take at home, Spravato is given in-office under medical supervision. This ensures safe use and allows your provider to monitor how you respond. Many patients describe a noticeable lifting of “the weight” that depression places on everyday life.

3. Your symptoms return after temporary improvement

Maybe you’ve had some success with medication in the past — only to feel symptoms creep back in. Treatment-resistant depression often shows up as a cycle of hope followed by relapse.

That’s where Spravato can make a difference. By targeting a different brain pathway than traditional antidepressants, it can break the cycle and help stabilize mood more effectively.

4. You’re experiencing acute suicidal ideation or behavior

Spravato is FDA-approved not only for treatment-resistant depression but also for adults with major depressive disorder who are experiencing acute suicidal thoughts or behaviors. 

In these cases, fast-acting treatment is critical. Unlike traditional antidepressants, which can take weeks to work, Spravato can help improve symptoms more rapidly in a monitored, supportive setting.

Finding hope when other treatments haven’t worked

At Revive Holistic Psychiatry, we believe no one should have to live with depression. If your symptoms haven’t improved with standard treatment, Spravato may be the next step toward healing.

Deciding on Spravato isn’t something you have to figure out alone. Dr. Adepoju evaluates your medical history, symptoms, and treatment response to determine if Spravato is right for you.

She considers:

• How many antidepressants you’ve tried and for how long
• How your symptoms impact your daily life and relationships
• Whether other conditions (like anxiety or PTSD) are involved
• Your goals and expectations for treatment

Call Revive Holistic Psychiatry today to schedule an appointment — or book online anytime — and take the first step toward finding relief.